L-Arabinose Studies

Updated: 2011-09-27   Source: 公司信息部   Clicks:

L-Arabinose Studies


A Study was conducted to investigate the effects of L-arabinose and related pentoses on the activities of intestinal alpha-glucosidases and pancreatic amylase in vitro, and to evaluate the effects of L-arabinose on glycemic responses using several experimental animals in vivo. The results showed that L-arabinose selectively inhibits intestinal sucrase activity in an incompetitive manner and suppresses the glycemic response after sucrose ingestion by inhibition of sucrase activity. ("L-Arabinose Selectively Inhibits Intestinal Sucrase in an Uncompetitive Manner and Suppresses Glycemic Response After Sucrose Ingestion in Animals," Kenji Seri, Kazuko Sanai, Noriki Matsuo, et al., Metabolism 1996; 45(11): 1368-1374).


In this animal study,  rats were fed 0-30g sucrose/100g diets containing 0-1g L-arabinose/100g for 10 days. Lipogenic enzyme activities and triacylglycerol concentrations in the liver were significantly increased by dietary sucrose, and arabinose significantly prevented these increases. The results suggest that L-arabinose inhibits intestinal sucrase activity, thereby reducing sucrose utilization, and consequently decreasing the amount of sugar that the body turns into fat. ("L-Arabinose Feeding Prevents Increases Due to Dietary Sucrose in Lipogenic Enzymes and Triacylglycerol Levels in Rats," Shigemtisu Osaki, Tomoe Kimura, Tomomi Sugimoto, et al., Journal of Nutrition 2001; 131: 796-799.)


A Study about the Effects of L-Arabinose on Intestinal Sucrase Activity in Man was carried out in 2005 .

The purpose of this study is to investigate the effect of L-arabinose in a sugar-rich meal on intestinal sucrase activity in healthy volunteers by measuring postprandial blood glucose and insulin, and selected intestinal hormonal responses to increasing doses of L-arabinose.



The Study assessed the ability of various natural substances, commonly referred to as "CHO blockers," to influence starch and sucrose absorption in vivo in ninety-six rats and two pigs. Groups of nine rats were fed water or water plus rice starch and/or sucrose; and circulating glucose was measured at timed intervals thereafter. For each variation in the protocol a total of at least nine different rats were studied with an equal number of internal controls on three different occasions. The pigs rapidly drank CHO and inhibitors in their drinking water. The results of the study support the hypothesis that the enzyme inhibitors examined at reasonable doses can safely lower the glycemic loads starch and sucrose. ("Inhibition by Natural Dietary Substances of Gastrointestinal Absorption of Starch and Sucrose in Rats and Pigs: Acute Studies," Harry Preuss, Bobby Echard, Debasis Bagchi, et al., Int'l Journal of Medical Sciences 2007; 4: 196-202.)


In 2009 ,A Whole study about the effect of L-arabinose in hyperglycemic  ,hypertension,hyperlipaemia ,Bifidobacteria,weight management was carried out in China by Healtang Biotech Co.,Ltd, and now according to the series of the study results , Healtang Biotech Co.,Ltd  had manufactured six Final products--Health product. In which the key ingredient is L-arabinose .

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